PGI Launches “Chromatography and TDM server” program in Memory of Late Dr Shyambalaji Achuthan

By 121 News

Chandigarh 17^th August:- The Department of Pharmacology, PGIMER, Chandigarh has launched an open source (GPL licensed), fully functional "Chromatography and TDM server" program, in commemoration of Late Dr Shyambalaji Achuthan who suddenly passed away on 18^thAugust, 2016. The program was inaugurated by Prof. Jagat Ram, Director PGI and Prof. D Behera, Dean(Research) on 17^th August, 2017 at 11:00 am in Lecture theatre of Pharmacology department, PGI, Chandigarh. 

The program has coded on high end R shiny language with ability to be scaled up to any height. The program has developed by group of scientists and researchers from PGIMER, for the following purposes: (i) the ease of calculating the unknown concentration of drug in the biological sample evaluated based on the concentration and spectral value of the standards (Obtained by using HPLC, LC-MS/MS or any similar Analytical/assay methods) instantaneously. (ii) Reutilization of the data for standard concentrations, for multiple samples. (iii) Creation of database containing the details of the samples evaluated with their results. (iv) Maintenance of easily accessible database within the laboratory along with functionality like downloading the database in csv format. (v) Evaluation of the database for finding out patients in the interested range of concentration in a instantaneous manner. In addition, the database can be accessed for conducting prospective/retrospective studies. (vi) Interactive analysis of the database to visualize out of range results within seconds. For identifying the samples which fall out of range, the date of entry of the results into the database or sample number of the patients can be taken as identifiers by this program. (vii) Interpretation of results hence obtained on basis of various parameters like the nature of the drug, patient criteria including age and any significant clinical conditions, drug interaction. (viii) Calculation of adjusted concentrations of drug in special conditions as suggested by published literature. An e.g. is, Correction of phenytoin concentration according to blood albumin concentration of the patient. This would mark as an important contribution to the global community of science as this program can be used by TDM laboratories all over the world especially by laboratories of the developing countries.

A presentation along with demonstration was made at same time by Dr Praveen Kumar. At the end of the presentation, the program repository was launched in the public domain. The institute's Director (Prof. Jagat Ram), Dean (Academic), Dean (Research), H.O.D. (Pharmacology) and other dignitaries had attended the inauguration. The GitHub link for accessing the source code of the program can be found at https://github.com/praveenkumarpgiindia/Chromatography-TDM-Server.  The program was organized by Prof. Bikash Medhi, his Experimental Pharmacology laboratory team, Department of Pharmacology, PGIMER, Chandigarh.