By 121 News
Chandigarh 10th June:- The study involving the use of human Umbilical cord blood derived lineage negative stem cells in rescuing mouse model of memory loss is India's first contribution to Neuroscience literature pertaining to disorders of ageing brain. The study has been published in the internationally reputed Journal, Behavioral Brain Research. The study employed various doses of stem cells, when injected into mouse brain, reversed memory loss induced by Abeta chemical which mimics Alzheimer's disease. The capacity to rescue memory loss by human cord derived stem cells will pave way for establishment of public cord banks as a source of stem cells for poor patients, if therapies are validated in future. At this time commercial banks charge huge fee for storing cord blood when a child is born. This study also showed that memory loss can be rescued without differentiation of stem cells, by simply inducing BDNF and CREB in mouse brain. This study was part of PhD work of Dr Avijit Banik who along with Dr S Prabhakar and Dr Jaswinder teamed up with the scientific approach defined by Dr Akshay Anand, Addl Prof, Neuroscience Research Lab, PGI Chandigarh so that the study could be taken to its logical conclusion. The proposal to examine consequent mechanisms involved is pending approval. This challenging study took five years to complete. The perspectives and implications of study are also planned to be presented at the upcoming International Brain Research Organisation meeting at Rio de Janeiro in July, 2015. This Neuroscience research group is learnt to be shortly coming out with a position statement in the field with major Neuroscience leaders in the world
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