By 121 News Reporter
Chandigarh 23rd November:- Dr. Tulika Gupta, Assistant Prof, Dept of Anatomy, PGIMER, Chandigarh received National Award - Dr Raikrushna Mohanti Award on "Mapping the time line of senescent changes in human retinal histology from third to tenth decade" in the National Conference of Anatomical Society of India held at Imphal.
Retinal pathologies causing irreversible visual loss are very common in India especially in advance age. Increased understanding of the age related structural and functional changes in retina can immensely help in better diagnostic and therapeutic modalities. Twenty five human retinal tissues from 22 years to 99 years of age were studied histologically and changes seen in each retinal layer were described. Retinal pigment epithelium showed, gradual reduction in cell size, melanin granules and increase in lipofucshin content & increase in bruch's membrane hyalinization with age. As age advanced there was reduction in the number of cones, thickness of the outer plexiform layer, Ganglion cell count and thickness of the nerve fibre layer. Special stains and specific immune labelled antibodies were used to understand the changes better. The thicknesses of all the retinal layers and the ganglion cell count have been documented decade wise. This detailed description may aid in improved management of diseases that are characterized by abnormal or premature aging as well as in understanding the age related retinal disorders. This data will also improve the interpretations of images of retinal micro anatomy obtained in patients by spectral domain-optical coherence tomography (SD-OCT), routinely used by ophthalmologists.
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